Abstract

MW ASSISTED SYNTHESIS AND BIOLOGICAL PREDICTION STUDY OF SOME NEW PYRAZOLE-4-CARBONITRILE DERIVATIVES USING MALONONITRILE

Savita Dhongade-Desai*, Poonam K. Shetake, Vitthal A. Divate and
Reshma P. Khot

Abstract

The different pyrazole-4-carbonitrile derivatives were synthesised by the reaction between thiophene-2-aldehyde (1 mmol) and malononitrile (1 mmol) under microwave irradiations at low power (210 W) with a catalytic amount of alcoholic sodium ethoxide followed by addition of phenyl hydrazine (1 mmol). The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, and Mass spectra. The biological activity of some new synthesized compounds was evaluated by PASS prediction and appeared to be significant.

Keywords: Pyrazole-4-carbonitrile, Heterocyclic aldehyde, microwave irradiations.