Abstract

DESIGN AND CHARACTERIZATION OF PHENYL EPHRINE HYDROCHLORIDE NASAL IN-SITU GEL

P. Jagadeesh*, N. Subbareddy, M. Bhargav, T. S. Nazma, M. Neeraja, N. Pushpalaha, S. Shamshad, T. Sharathbabu, P. Sunitha and B. Yellasivamma

Abstract

In order to improve the bioavailability of the phenylephrine hydrochloride, in situ mucoadhesive thermo reversible gel was formulated using poloxamer 407 as thermo reversible polymer, chitosan and sodium alginate was used as mucoadhesive polymers Results revealed that as mucoadhesive polymer increased the mucoadhesive strength increased but gelation temperature decreased. Formulation was optimized on the basis of clarity, pH, gelation temperature, mucoadhesive strength, viscosity, drug content. The final formulation released 95.43±1.29% drug in 120min and gelation temperature was 37±0.2°C. Drug excipients compatability studies were conducted by FT-IR spectroscopy and result release studies shown that formulations F11 release the drug 99 percentage at the end of 120 mins.

Keywords: Phenylephrine HCL, Polaxomer 407, Chitosan, HPMC.