Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF OLMESARTAN MEDOXOMIL USING SYLYSIA

Anuska Padhy*, Debasis Ghose, Gautam Kumar Jena and Ch. Niranjan Patra

Abstract

Olmesartan Medoxomil used as antihypertensive drug belongs to BCS class II. It has less aqueous solubility and high permeability. Due to less aqueous solubility it exhibits low oral bioavailability i.e. 26% only. The primary objective of the present research was to improve the aqueous solubility and in vitro dissolution rate of Olmesartan Medoxomil using different grades of porous carrier sylysia i.e. sylysia 350, sylysia 550 and sylysia 730. The FT-IR and DSC study confirmed no interaction between drug and sylysia. The solid dispersions were prepared by solvent evaporation method. The solid dispersions exhibited desirable flow properties for processing into tablet dosage forms. In vitro dissolution study of all solid dispersions showed highest dissolution rate for sylysia 550(98.2) based solid dispersions. The solid dispersion with highest solubility was compressed into immediate release tablet with sodium starch glycolate as super disintegrating agents. The tablets with 25% of sodium starch glycolate showed quick disintegration and similar dissolution rates as that of the optimized solid dispersion.

Keywords: solubility, porous carrier and tablet.