Abstract

ADAPTOGENIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF TRIPHALA IN ALBINO RATS

Diptimayee Jena*, Sambhunath Saha, Bimalendu Chowdhury, M. E. Bhanoji Rao

Abstract

The present study was designed to perform the adaptogenic activity of hydroalcoholic extract of Triphala fruit (HAETF) part. The adaptogenic activity was evaluated by administering acute and chronic dose of HAETF in albino rats. The rats were randomly divided into five groups. Group one was not subjected to stress and were kept as normal control, group two was subjected to stress and were kept as stress control and other groups were treated with different dose of HAETF i.e. 100, 200 and 400 mg/kg p.o. and the adaptogenic activity was studied on acute swim endurance stress model and chronic swim endurance stress model for acute and chronic study respectively. In acute stress models, VMA level of the stress control rat was 21.42±1.49μg/ml and the normal control showed a VMA level of 3.92±1.39μg/ml which was statistically significant(p

Keywords: VMA, plasma SGOT, brain MDA, force swim endurance stress model.