Abstract

EFFECT OF CINNAMALDEHYDE ON ADJUVANT INDUCED ARTHRITIS IN RATS

K. Padhi*, R. Somani and D. Pradhan

Abstract

Cinnamaldehyde is a phytoconstituent that is abundantly found in various plant species like Cinnamomum osmophloeum Kaneh, Cinnamomum cassia Presl and various species of Cinnamomum. Cinnamaldehyde is a natural product from spices that has many pharmacological activities. It belongs to the terpene group of compounds. We investigated the effect of Cinnamaldehyde on adjuvant induced arthritis in rats. Female Wistar rats were divided into 6 groups having 6 animals in each group (n=6). Arthritis was induced by injecting 0.1 ml of CFA into the surface of the left hind paw. Drug or vehicle treatment was started on day 5 till day 28 in prophylactic protocol and on day 16 till day 25 for the therapeutic protocol. All the characteristic features of rheumatoid arthritis like weight loss, Rheumatoid factor and C-reactive protein, Radiological deformation and biochemical parameters are significantly attenuated by Cinnamaldehyde demonstrating its beneficial effect for rheumatoid arthritis.

Keywords: Cinnamaldehyde, adjuvant induced arthritis.