Abstract

PHARMACOLOGICAL STUDY AND EVALUATION OF ANTIANXIETY ACTIVITY OF LEAVES OF AZIMA TETRACANTHA

Manasi Khadanga*, Durgamadhav Dash, Pratit Kanchan Sahu and Sujit Ku. Martha

Abstract

Pathological anxiety is one of the most common mental disorders in humans. Anxiolytic drugs, mostly belongings to benzodiazepines (BDZ) group & serotonergic groups are widely used to treat antianxiety. However the clinical use of these established drugs are associated with a lot of adverse effects.[1] Therefore the development of new drug agent possessing anxiolytic effect with minimal or no adverse effect would be great importance in the treatment of anxiety related disorder. Very high performance is given to the phytoconstituents by the scientific community. for a new anxiolytic agent administered orally for 10 days to Wistar rats for screening effects of anxiolytic effect by using Elevated plus maze (EPM) & Light Dark arnea (LAD)test.[3] The result of our study demonstrated that the ethanolic extract of azima tetracantha leaves has significant anxiolytic activity in EPM & LAD models of anxiety abd supports the traditional use of this plant.[4]

Keywords: ethanolic extract, elevated plus maze, light dark arnea, BDZ group.