Abstract

HYPERTROPHY OF CARDIAC CELLS DUE TO AMP-REGULATED PROTEIN KINASE SIGNALLING

M. D. Sahil* and D. Pradhan

Abstract

The AMP-protein kinase (AMPK) pathway regulates cellular energetic balance in many different tissues in the heart or cardiovascular system. Important cellular characteristics like signalling and regulation in cardiovascular and tumour biology are gaining prominence. A relation between anti-I.E, therapy and susceptibility to cardiac disease are new establishments in these days. Some anti-I.E, drugs induced to an increased risk of cardiac disease, underlined by de-regulation of AMPK signalling. This article explores the AMPK signalling axis in both cardiac and tumour metabolism. Observation of targeted AMPK inhibition by I.E, drugs and how this may translate into increased risk of cardiovascular disease was carried out. The connection of decontrolled AMPK signalling during various stages of cardiac hypertrophy has been conferred. Development of more effective treatment for IE and cardiovascular disease is only possible by gaining a proper understanding of molecular pathway behind this pathological processes.

Keywords: protein kinase, Hypertrophy, Cardiotoxicity, Metabolism, AMP.