Abstract

EFFECT OFCALCIUM AND ZINC ON THE IN-VITRO DRUG RELEASE AND CROSS-LINKING BEHAVIOR OF CAPECITABINE LOADED SODIUM ALGINATE MICROBEADS.

Shreyasi Banerjee*, Dr. Ch. Niranjan Patra and G. K. Jena

Abstract

Capecitabine is currently approved by the US Food and Drug Administration (FDA) for use as first-line therapy in patients with metastatic colorectal cancer when single-agent fluoropyrimidine therapy is preferred. The dose of capecitabine approved by the FDA for both metastatic colorectal and breast cancer is 1250 mg/m2 given orally twice per day. In order to reduce dose, dosing frequency, side effect and sustain the drug release, sodium alginate microbeads can be developed. The aim of the present research was to develop sodium alginate microbeads by emulsification method using calcium chloride and zinc sulphate solution individually and combined and compares the in-vitro drug release profile of microbeads.

Keywords: Capecitabine, Colorectal cancer, Microbeads, Fluoropyrimidine.