Abstract

NANOPARTICLES: AN OVERVIEW

Bhagyashree Patil*, Sarita Sharma, Priya Hargunani, Aruna Pai, Dr. Ashish Jain

Abstract

Nanotechnology is most emerging technique in Pharmaceutical sciences. It has been used to improve pharmacokinetic & pharmacodynamic properties of any drug molecule. Nanoparticles ranging from 1 to 100nm with different dimentions. Nanoparticles are used to restrict acess of drug to chosen sites, To deliver the drug at controlled & sustained rate to the site of action and to protect the drug entity in the systemic circulations. Various Polymer have been used in the formulation of nanoparticles to increase therapeutic benefit, while minimizing the side effect. Several techniques used for preparation of nanoparticle like Double emulsion method, Emulsion-diffusion method, Solvent evaporation, Nanoprecipitation, Coacervation method, Salting out method, Dialysis & Supercritical fluid technology. Nanoparticles are subjected to several evaluation parameters such as yield of nanoparticles, Drug Content / Surface entrapment / Drug entrapment, Particle Size and Zeta Potential, Surface Morphology, Polydispersity index, In-vitro release Study, Kinetic Study, Stability of nanoparticles.

Keywords: Nanoparticles, Nanotechnology, Techniques, Polymer.