Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT OF BACOLEPIS NERVOSA DECNE. EX. MOQ. USING CARRAGEENAN INDUCED PAW OEDEMA IN ALBINO RATS

Arockia Jenecius and Veerabahu Ramasamy Mohan*

Abstract

The present study was conducted to evaluate the anti-inflammatoryactivity in ethanol extracts of stem and leaves of Bacolepis nervosa.The anti-inflammatory activity was assessed by carrageenan inducedpaw oedema in albino rats. The stem and leaf extracts of this plantwere administered orally at doses of 150 and 300 mg / kg body weightand the study was compared with a standard drug indomethacin (10 mg/ kg). The highest dose of B. nervosa stem and leaf extracts (300 mg /kg) produced a maximum inhibition of 82.28% and 79.64% at 3 hoursafter administration respectively. The anti-inflammatory activity ismore effective in group V carrageenan induction with oraladministration of B. nervosa stem extract of 300 mg/kg body weightcompared to standard drug and leaf extract. Further and detailed studies are in progress forthe isolation of single entity responsible for anti-inflammatory activity and development ofsuitable formulations.

Keywords: Carrageenan, Bacolepis nervosa, indomethacin, anti-inflammatory.