Abstract

CARDIOPROTECTIVE POTENTIAL OF TRIDAX PROCUMBENS AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN EXPERIMENTAL RATS

A. Shanmugapriya* and S. Maneemegalai

Abstract

Myocardial infarction is one of the major killer diseases among industrialized nations. Various medicinal plants are available that exhibit potential cardioprotective properties. In the present study, the ethanolic extract of Tridax procumbens in various concentrations were studied for screening the cardioprotective activity against isoproterenol induced myocardial infarction in albino rats. Serum marker enzymes like Aspartate Transminase (AST), Alanine Transaminase (ALT), Acid Phosphatase (ACP) and Alkaline Phosphatase (ALP), lipid profile, lipoproteins were determined in serum of experimental animals. Since the induction of Myocardial infarction is accompanied by the generation of free radicals, the role of antioxidants in heart tissue has been studied in experimental animals. The ethanolic extract of Tridax procumbens showed significant cardioprotective effect by reducing the level of biochemical parameters like marker enzymes, lipid profile and lipoproteins like LDL and VLDL in increasing concentration. Treatment with Tridax procumbens considerably restored the levels of antioxidants with increasing concentration. The results clearly demonstrate that the active phytoconstituents present in Tridax procumbens ethanolic extract protects myocardium against isoproterenol induced myocardial infarction.

Keywords: Ethanol, isoproterenol, antioxidants, myocardial infarction, markers.