Abstract

ORAL IN-SITU GEL FOR PERIODONTITIS: A REVIEW

Sanheeta Chakrabarty* and Bipul Nath

Abstract

In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications including drug delivery systems. In this review, we highlight the methods of oral in-situ hydrogel in the context of drug delivery and tissue repairing for periodontitis. Oral in-situ gel is found to be the most suitable type of formulation for the treatment of periodontitis, that delivers the drug locally, as a result, dose can be reduced as well as toxicity can be minimised. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The article provides insight on natural polymers as well as synthetic polymers, including systems based on thermally triggered system, pH triggered system, ionic cross linking method, enzymatic cross linking method etc. Lastly, this review summarize about the characterization of oral in situ gels including different evaluation such as drug content study, pH & viscosity determination, texture analysis, spreadibility, gel strength, gelling time, sterility testing, in-vitro drug release study, stability study etc.

Keywords: Periodontitis, in-situ, Oral Gel, Polymers, Evaluation.