Abstract

FORMULATION AND EVALUATION OF MICROSPHERES OF GLIPIZIDE

Angadi Jyothi*, K. Samhitha, P. Sindhu and Chandu Babu Rao

Abstract

Microspheres constitute an important part of drug delivery systems by virtue of their small size and reliable means to deliver the drug to the target site with specificity. However, the advantages of microspheres. The prepared microspheres were characterized for various physicochemical parameters such as particle size, percentage yield, encapsulation efficiency, scanning electron microscopy, in-vitro drug release and kinetics study. The in-vitro drug release studies were performed in buffer media and shown the controlled release pattern of drug up to 10 hours. Drug release from the microspheres was found following zero order release kinetics with non-fickian release mechanism. The satisfactory results were obtained in all prepared formulations and based on the results F4 was best formulation when compared to other formulations

Keywords: Microspheres, Glipizide, Eudragit, Invitro release, regression co-efficient.