Abstract

ACUTE AND 28 DAY REPEATED ORAL TOXICITY STUDY OF SIDDHA HERBOMINERAL FORMULATION LINGA MATHIRAI IN RATS

Dr. A. Shanuvas* and Dr. M. Indhumathi

Abstract

The Herbo mineral formulation Linga mathirai is indicated for Diabetes mellitus in Siddha system. The drug Linga mathirai is made as per Siddha literature. Recent scientific trends insisting that administration of metals in human usage should undergo the toxicity studies. The aim of the present investigation was to evaluate acute and sub acute toxicity of the Linga mathirai on wistar rats following OECD guidelines. In acute oral toxicity study, a single dose of Linga mathirai was administered and observed for 14 days, no abnormal signs upto the dose level of 2000mg/kg body weight. Sub-acute toxicity studies were carried in two different groups of Linga mathirai was administrated orally to rats once daily for 28 days in various doses ranging from 100 and 200 mg/kg for rat respectively. The study concludes there were no change in behaviour movements and no characteristic clinical sign of toxicity or mortality observed.

Keywords: Linga Mathirai, Acute toxicity, Repeated 28 days toxicity, OECD guidelines.