Abstract

FORMULATION AND INVITRO EVALUATION OF GASTRORETENTIVE FLOATING MATRIX TABLETS OF ETODOLAC

*N. Rajitha, V. Lokeswara Babu and A. Srinivasa Rao

Abstract

In the present work, an attempt has been made to develop In vitro Evaluation of Gastroretentive Floating Matrix tablets of Etodolac. Novel method of Gastroretentive Floating Matrix technology was employed to formulate the tablets. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 was considered as best formulation after considering all the evaluation parameters. In vivo evaluations were performed later for the selected best formulation.

Keywords: Etodolac, Gastroretentive Floating Matrix, Blend, Direct compression, quality control, parameters.