Abstract

PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY OF WATER SOLUBLE CURCUMIN POLYMERIC PRODRUG

Dr. Mudra Kapoor*, Dr. Sudha Rathod and Dr. Mariam Degani

Abstract

Curcumin has diferuloylmethane nucleus effective in treating bacterial and fungal manifestation. Poor solubility and reduced systemic bioavailability compromises its therapeutic potential. To circumvent this problem we have chemically conjugated curcumin to biodegradable and bioadhesive poly (methylvinyl ether/maleic anhydride) via ester linkage. The amphiphilic nature of polymeric prodrug of curcumin has exhibited improved aqueous solubility of 14.54 gm/L, 53 times higher compared to pure curcumin, hydrolytic stability at pH 7.4 for 7 hrs with bioadhesive potential. The photodynamic therapy potential of conjugate evaluated at 460nm at 50J/cm2 performed invitro against microbial strains-gram negative E. coli. ATCC 25922, gram positive S. aureus ATCC 2654 and Candida albicans ATCC 2091 revealed 50% increase in antimicrobial activity compared to the native drug. The product has demonstrated remarkable antimicrobial activity and can have potential use in skin, oral and dental antimicrobial applications.

Keywords: Curcumin, poly (methylvinyl ether/maleic anhydride), conjugate, photodynamic, antimicrobial.