Abstract

REVIEW ON IN-SITU NASAL GEL DRUG DELIVERY SYSTEM

Mahesh K. Borse* and R. B. Saudagar

Abstract

The critique was carried out to discuss in detail about the in-situ gel nasal drug delivery system as these system have better systemic bioavailability through nasal route as compared to oral route of administration. In-situ gel may be novel indefinite quantity kind for nasal delivery of varied medication. It‟s infusing into the nasal cavity as low viscous solution and after someday it forms gel once it contact with the nasal mucosa membrane. The most advantage of victimization nasal delivery is shunning of first pass metabolism, high porosity of some medications in nasal epithelium tissue, fast drug absorption across this membrane, rapid onset of action, improved patient compliance and comfort, sustained and prolonged action in compared to different drug delivery systems. The formation of gel depends on factors like temperature modulation, pH change, presence of ions, ultra violet irradiation, polymorphism, dissolution rate, solubility, viscosity and osmolarity. The review was targeted.on anatomy and physiology of nose, advantages, disadvantages, mechanism of drug delivery to the nose, forms of dosage kind for nasal delivery, barriers in nasal drug delivery, factors influencing nasal absorption, mucoadhesive polymer ustilized in nasal drug delivery system and analysis of in-situ gel nasal drug delivery system.

Keywords: In-situ gel, nasal mucosa, Bioavailabilty, novel dosage form, first pass metabolism.