Abstract

ANTIDIABETIC ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF PASSIFLORA FOETIDA L. IN ALLOXAN INDUCED DIABETES RATS

P. Joseph Asir, S. Hemmalakshmi, S. Priyanga and K.Devaki 

Abstract

The aim of the present investigation was to evaluate the antidiabetic efficacy of aqueous and ethanolic extracts of Passiflora foetida L. againts alloxan induced diabetes rats. Wistar albino rats were used for the present study and the animals were divided into 12 groups. Diabetes was induced by a single intraperitoneal injection of alloxan monohydrate (100 mg/kg) in saline. Aqueous and ethanolic extracts of Passiflora foetida L. 200 mg/kg (leaf, unripe (UR) peel, full ripens (FR) peel, seed and root) was administered orally for 14 days. All the animals were sacrificed after 14 days treatment and its effect on blood glucose, Glucose tolerance test (GTT), hepatic marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum marker like urea, creatinine and protein in alloxan induced diabetic rats were examined.The results showed that the aqueous extract of P. foetida L. showed maximum percent reduction of glucose when compare to ethanolic extract of P. foetida L. The aqueous and ethanolic extracts of P. foetida L. also have the ability to decrease the level of serum SGOT, SGPT, urea and creatinine significantly in diabetic condition.The present study proved that the aqueous and ethanolic leaf extract of P. foetida L. had the best antidiabetic activity with a maximum percent reduction of glucose.

Keywords: Passiflora foetida L., Antidiabetic, Alloxan, GTT, Urea, Creatinine.