Abstract

OPENING NOVEL WAYS IN THE DRUG DELIVERY SYSTEMS BY BI-LAYER TABLET TECHNOLOGY

Abhishek R. Bura*, Amit N. Chavan and Gaurav Lodha

Abstract

For patent extension, few pharmaceutical companies are currently developing the bi-layer tablets, addition in therapeutic efficacy etc. Bilayer tablet is a novel era for the unbeaten development of controlled release formulation along by various features to provide a method of successful drug delivery system and for separation of two incompatible substances two drugs are used in combination for sequential release and as initial dose sustained release tablet in which one layer is immediate release and the second layer is maintenance dose. Bi-layer tablets can be major option to avoid chemical incompatibilities among APIs by physical separation and to allow the development of dissimilar drug release profiles. The present article provides a review of the oral drug delivery system, types of the tablets, Bilayer tablet developing, various type of tablet presses use, quality and the GMP requirements for high production output and current developments in the field of Bilayer technology and production of superiority bi-layer tablets need to be carried out on the reason built tablet presses, such as layer parting, lacking in hardness, incorrect individual layer weight control, cross-contamination among the layers and reduced the yield.

Keywords: Bilayer tablet, GMP requirements, DUROS Technology, tablet presses, Trilayer tablets.