Abstract

EVALUATION OF PULSE THERAPY IN PEMPHIGUS

Dr. B. Amrutha, Dr. C. N. Harshitha, Dr. K. Bharath, Dr. Shagufta Gulnar, *S. Aruna and Dr. K. Abbulu

Abstract

Introduction: In Pemphigus, pulse therapy refers to intravenous (IV) infusion of high doses of steroids for one or more days for quicker, better efficacy, and to decrease the side effects of long-term steroids. Objective: To assess the risk benefit ratio of pulse therapy in Pemphigus diseases. Methodology: We have conducted a prospective study for a period of 6 months (August 2016 – January 2017) In inpatient Departments of Dermatology, Gandhi hospital, Secunderabad. In this study we have included 45 number of patients. Results: In our study we found that the disease was more prevalent in the middle age group of 21-30years. Out of 45 patients 32 patients were given DCP and 13 patients were given DAP. Our study showed that in initial visits safety parameters were found to be high than efficacy but in later visits efficacy increased because patient was prescribed with supportive therapy to monitor safety parameter. Conclusion: The disease condition showed remarkable declination regardless of their severity conditionally if patient received regular, rational and complete treatment. Studies with more number of patients and for longer period will help in better management of patient and disease. Hence we conclude that our study provides a hypothesis for future studies which can emphasize on our advantages of Pulsetherapy.

Keywords: Pemphigus, Pulse therapy, long-term steroids, Risk benefit ratio.