Abstract

A CASE REPORT ON STEROID RESISTANT NEPHROTIC SYNDROME (SRNS)

Chatharaju Bhavani*, P. Srivani, Prithi Ambati and K. Abbulu

Abstract

Intro: Steroid Resistant Nephrotic Syndrome (SRNS) is a disease that causes abnormalities in kidney function, often leads to kidney failure. 70-90% Nephrotic Syndrome (NS) cases under the age of 10 years and 50% NS cases in between 10-15 years children are due to Minimal Change Disease (MCD). In most of the cases the underlying cause for SRNS is not known. Symptoms such as excess of cholesterol and triglycerides in the blood, presence of proteinuria, shortage of protien in the blood. SRNS requires kidney biopsy to define histopathology. Nephrotic syndrome makes people vulnerable to infections while they are swollen and also increase their risk of developing thrombosis. Management of children with SRNS requires confirmation of resistance to a particular drug in corticosteroids for a minimum of 8 weeks. Case Report: A 5 years old male child came with the complaints of swelling of the face followed by swelling of the body, increase in weight since 2 months and foamy urine since 10 days. The child was asymptomatic 2 months back then slowly developed swelling of face and the body. Child was known case of NS, biopsy proven MCD 2 years back, was on regular Prednisolone therapy 15mg bd, Metolazone 2.5 mg od since 3 years. Based on the physical examination and clinical features patient was diagnosed as Steroid Resistant Nephrotic Syndrome.

Keywords: Proteinuria, Corticosteroids, Triglycerides, Cholesterol, MCD.