Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ZIDOVUDINE USING SUBLIMATION TECHNIQUE

CH. Jyothi*, K. Akhil Kumar, M. Mamatha, N. Mamatha, G. Soujanya and Dr. K. Hemamalini

Abstract

The aim of the present study was to formulate and evaluate the fast dissolving tablets of Zidovudine. Zidovudine is an antiretroviral drug commonly used in the treatment HIV infection. The superdisintegrants used in this study was sodium starch glycolate and cross Carmellose sodium by sublimation method. The tablets were evaluated for weight variation, hardness, wetting time, friability, water absorption ratio and disintegration time and In vitro dissolution study. The tablets were prepared by direct compression method. All tablet formulations showed quick disintegration time, which is very characteristic of fast dissolving tablets. All the formulations showed rapid percentage drug release (28.42% - 98.51%)). The rapid drug disintegration (18 sec) was noticed in F8 formulation when compare to other formulation, which release 98.51% at the end of 30 minutes. The fast dissolution might be due to quick disintegration of the tablet to form particles and rapid absorption will process superdisintegrant was considered as the optimised formulation. The in vitro drug release profile of the optimised formulation is F8.

Keywords: Direct compression, Fast dissolving tablet, Cross Carmellose Sodium, Sodium Starch Glycolate, Sublimation technique, Zidovudine.