Abstract

EFFECT OF ETHANOLIC EXTRACTS OF Amorphophallus paeoniifolius AND Gymnema sylvestre ON FEMALE WISTAR RATS WITH ESTRADIOL INDUCED POLYCYSTIC OVARIAN SYNDROME

Sreesaila N. P.* and Dr. P. Nirmala

Abstract

The study was designed to investigate the effect of plant parts of Amorphophallus paeoniifolius and Gymnema sylvestre on Polycystic ovarian disease induced by Estradiol valerate on Wistar rats. Six groups of rats were used for the study. Control, Estradiol, Standard - Metformin, Amorphophallus paeoniifolius extract, Gymnema sylvestre extract and their combination were the six groups. The extracts were provided orally for two weeks. The vaginal smear study were carried out with the rats from each of the groups, shows the presence of menstrous cyclicity in the control group, and also in treated groups (standard-Metformin, Amorphophallus paeoniifolius extract, Gymnema sylvestre extract and their combination). The hormonal analyses from the blood serum of the rats were the result of effective variation of LH, FSH, and Androgen levels as compared with the Metformin standard. The histopathological study proved the synergetic effect of Amorphophallus paeoniifolius and Gymnema sylvestre extracts in reducing the risk of Polycystic ovarian syndrome owing to the decrease in follicular cystic formation. Therefore it explores the possibility of developing a drug by combining Amorphophallus paeoniifolius, Gymnema sylvestre extracts to cure Polycystic ovarian syndrome without any side effects.

Keywords: Pcos, LH, FSH, Androgen.