Abstract

SYNTHESIS AND CHARACTERIZATION OF AZETIDINE ANALOGOUS AND RELATED COMPOUNDS FOR THEIR ANTIMICROBIAL ACTIVITY

Phool Singh Yaduwanshi*, Vinod Gauttam, Dhanraj Patidar and
Prashant Kumar Dubey

Abstract

A new series of azetidine analogous designed and synthesized to meet the structural requirements essential for antimicrobial activity. Substituted derivatives of azetidine analogues and related compounds had been synthesized using salicylic acid as a starting material. All the synthesized compounds were screened for antimicrobial activity by zone of inhibition method. The standard drugs used for the present study were ampicillin as antibacterial and griseofulvin as antifungal. The synthesized compounds exhibited significant antimicrobial activity comparable to the standard drugs. Among these synthesized compounds, compound code D1and D2 showed maximum activity.

Keywords: Antimicrobial, Azetidine, Cyclization Reaction, Heterocyclic chemistry.