Abstract

HEPATOPROTECTIVE ACTIVITY OF INDIGOFERA TRIFOLIATA AGAINST PARACETAMOL INDUCED HPATOTOXICITY IN ALBINO RATS

Mangesh K. Kaware and Varsha S. Zade*

Abstract

Indigofera trifoliata is a shrub which has been traditionally used to cure Hepatitis, cirrhosis, Jaundice etc. However the scientific evaluation of its hepatoprotective role was lacking. Hence in the present study, hepatoprotective activity of ethanol extract of Indigofera trifoliata was investigated in paracetamol intoxicated albino wistar rats. Paracetamol induced albino rats produced a marked elevation in the level of Biochemical markers (SGOT, SGPT, Bilirubin, ALP, Cholesterol and Total protein), which showed a marked decrease after oral administration of Indigofera trifoliate extract (150mg/kg and 200mg/kg doses). The results were comparable to the effect of the standard drug Silymarin. The histopathological analysis also supported the finding of blood biochemical parameter analysis, thus confirming the hepatoprotective role of Indigofera trifoliata.

Keywords: Hepatoprotective, Indigofera trifoliata, albino rats, herbal drug, paracetamol.