Abstract

A SIMPLE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF PANTOPRAZOLE IN PHARMACEUTICAL PREPARATIONS

M. Ramesh Kumar, B. Krupender Reddy, K. Prabhavathi and N. Rami Reddy*

Abstract

A simple, sensitive and accurate spectrophotometric method has been developed for the assay of Pantoprazole in pharmaceutical preparation. The method is based on the reaction of each drug with wool fast blue, the formed complex extracted into chloroform at pH 1.5. The absorbance of ion pair complex form in extractable chloroform layer is measured at the wavelength of maximum absorbance for each drug against the reagent blank and the amount of drug is determined from the calibration curve made between the absorbance and the amount of drug. The amount of drug is computed from the calibration curve.

Keywords: Spectrophotometry, wool fast blue, pantoprazole, Pharmaceutical and Formulation.