Abstract

EVOLVING CONCEPTS AND TARGETING OF ARTHRITIS

Gyanesh Kumar Sahu, Harish Sharma, Chanchal Deep Kaur

Abstract

Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the different types of arthritis domains that lead to the generation of painful sensation. When inflammation, joint nerves become sensitized to mechanical stimuli through the actions of neuropeptides, proteinase-activated receptors ion channel ligands and eicosanoids. Early diagnosis and effective treatment is considered to be important in the prevention of disability and joint damage in patients with arthritis. This review has led to the establishment of introducing different types of arthritis, an overview of implicated drugs and their principle of targeting. There are various categories of medicines used for the treatment of arthritis with their own side effects. The targeting approach with novel delivery systems and use of phytoconstituents are the evolving areas of research for the treatment of various types of arthritis. The amalgamagation of both the approaches could create new avenues of treatment therapy.

Keywords: Rheumatoid Arthritis, Osteoarthritis, Fibromyalgia, Gout, Lupus.