Abstract

EXTRACTION AND EXVIVO CHARACTERIZATION OF VARIOUS NATURAL MUCOADHESIVE POLYMERS

Pallavi K.*, Naveen Babu K. and M. V. Basaveswararao

Abstract

A stable, non-toxic, economical and compatible dosage form can be achieved with the right choice of the excipients. Use of natural polymers instead of synthetic polymers, aids in the development of a dosage form that is safer, with minimal side effects. The present study envisaged the extraction of mucoadhesive polymers from natural ingredients like Abelmoscusesculentus fruits, Hibiscus rosa-sinensis leaves, Artocarpusheterophyllus fruit, Linumusitatissimum seeds and Colocasiaesculenta corms. All the extracted mucoadhesives were preliminarily evaluated using Molisch’s test, Iodine test, enzyme test and Ruthenium test. Exvivo evaluation of extracted mucoadhesive was executed using Wash off test performed using modified disintegration apparatus and Mucoadhesive bond strength test performed using modified digital balance apparatus. The results revealed that Linum seed gum (M4) has highest mucoadhesive bond strength of 0.091N/m2 and a force of adhesion 1.601 N followed by Artocarpus fruit gum (M3). Furthermore the results conclude that the extracted mucoadhesive serve as a best alternative for the existing synthetic mucoadhesives in formulating safer and cost effective dosage forms.

Keywords: Natural, Mucoadhesive, Extraction, Bond strength, Wash off test.