Abstract

SOLUBILITY AND DISSOLUTION ENHANCEMENT OF VALSATAN BY SOLID DISPERSION TECHNIQUE USING NATURAL POLYMER

S. B. Sapkal*, S. A. Shinde, R. A. Darakhe, Sarin Chavan, V. B. Patond and Dr. J. Krishna

Abstract

The purpose of this study was to prepare and characterize solid dispersions of the poorly water soluble antihypertensive agent valsartan with natural carriers such as Xanthan gum, gaur gum and gum acacia to improve its aqueous solubility and rate of dissolution by solvent evaporation technique. All the formulations showed marked improvement in the solubility behavior and improved drug release. From all the formulations VS7 was found to be optimized formulation based on the characterization, solubility and dissolution studies. The results obtained showed that the aqueous solubility and rate of dissolution was significantly improved when formulated in solid dispersion as compare to pure drug. The enhancement of dissolution rate depends on the nature and amount of the carrier and increases with the increase in the concentration of the carrier. Increase in the dissolution rate may be attributed to; the reduced particle size of drug deposited on the surface of carrier and enhanced wettability of the drug particles by the carrier. The optimized formulations were evaluated by X-ray diffractometry (XRD), Differential scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM).

Keywords: Valsartan, solid dispersions, Xanthan gum, gaur gum, gum acacia, solubility.