Abstract

ANTIDIARRHEAL ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF FIMBRISTYLIS BISUMBELLATA

Dr. Abubakar Salam Bawazir*, Rafiuddin Naser and Mohammed Khalilullah

Abstract

Fimbristylis bisumbellata is a plant belonging to the family Cyperaceae. Antidiarrheal effect of aqueous leaves extract of Fimbristylis bisumbellata was evaluated in female wistar rats. A preliminary phytochemical screening of aqueous extract of leaves of Fimbristylis bisumbellata gave positive tests for tannins. Studies were carried out on in-vivo gastrointestinal motility, on castor oil induced diarrhea in rats. 200mg/kg and 400mg/kg doses were used against castor oil induced diarrhea in rats against loperamide as a standard. The extract showed decrease in number of stools within 12 hours and increase in diarrhea free period. Results obtained showed that the aqueous extract of leaves has significant Antidiarrheal activity. Present research aspects is an honest presentation of the determination of activities possessed by chemical constituents in the leaves of plant Fimbristylis bisumbellata. Significantly it shows Antidiarrheal against experimentally induced Castor oil diarrhea.

Keywords: Fimbristylis bisumbellata.