Abstract

COMPARATIVE ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF PEEL AND PULP OF FRUITS OF FICUS CARICA L.

Arumugam P.*, Haritha M., Keerthana R., Vijayalakshmi M. and Saraswathi K.

Abstract

The beneficial medicinal effects of naturally available products originally results from the combination of secondary metabolites present in the plant including parts such as leaves, root, tubers, peel, etc. The aim of the present study was to evaluate the antioxidant, antimicrobial and antiproliferative activities of peel and pulp of fruits of Ficus carica (Family: Moraceae). The IC50 of DPPH˙ radical and ABTS•+ radical cation scavenging assays were 63.89 and 19.51μg/mL concentration respectively. Also, the RC50 of phosphomolybdenum reduction and ferric reducing power assay were 13.51 and 18.11μg/mL concentration respectively. Also, total phenolic and flavonoid content were determined, in which phenols were found to be predominantly higher. Peel extract of Ficus carica exhibited potent antioxidant activity when compared to pulp extract. The antibacterial activity was effective for peel extract by agar well diffusion method. The active compounds were identified by GC-MS analysis which revealed the presence of Thionodecalactone, Pentadecanoic acid, 4H-Pyran-4-one. The cytotoxic effect for the peel extract against colon cancer cells exhibited 79.96% at 100μg/mL concentration.

Keywords: Free radicals, Ficus carica, Antioxidant, DPPH? radical, ABTS•+ radical cation, RC50, colon cancer.