Abstract

HYPERLIPIDEMIA: TREATMENT MODALITY AND BUSTING MYTHS OF DIETARY APPROACH

Ranjodh Jeet Singh, Kanika Kohli*, Ashwani Kumar Gupta and Shalini Gupta

Abstract

The patients of Hyperlipidemia constitute abnormality in raised serum concentrations of LDL and total average Cholesterol as well as rise of TGs. Thus these patients have a higher risk of accentuating atherosclerotic changes at early age, while drug therapy to decrease the raised serum levels of average cholesterol, TGs, LDL and VLDL must be necessitated properly. Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-induced conditions, such as CAD. The incidence and absolute number of annual events will likely increase over the next decade because of the epidemic of obesity and the aging. Dyslipidemia including Hyperlipidemia (hypercholesterolemia) and low levels of HDL-C are major causes of increased atherogenic risk; both genetic disorders and lifestyle (sedentary behavior and diets high in calories, saturated fat, and cholesterol) contribute to the dyslipidemia seen in countries around the world. For many individuals, alterations in lifestyle have a far greater potential for reducing vascular disease risk and at a lower cost than drug therapy. When pharmacotherapy is indicated, providers can choose from multiple agents with proven efficacy. Thus the lifestyle modification including the dietary module approach and strict implementation of desired pharmacotherapy as either monotherapy as single drug or as combination therapy which comprises of two or more drugs necessitated with appropriate psychological reinforcement counseling for smoking cessation and restriction of alcohol. As exercise leads to increase in HDL cholesterol and decrease in TGs level while dietary approaches eventually lead to decrease in TGs levels, LDL cholesterol, total serum cholesterol. Thus it seems directly to synergize role of exercise with dietary module approach. Conclusion: The pharmacotherapy must be combined with dietary approach and necessary lifestyle modifications must be implemented for good outcomes.

Keywords: LDL-c: low density lipoprotein-cholesterol, HDL-c: high density lipoprotein cholesterol, TGs: triglycerides, VLDL-c: very low density lipoprotein cholesterol, CVS: cardio vascular system, BP: blood pressure, CAD: coronary artery disease, SFAs: saturated f