Abstract

FORMULATION OF KETACONAZOLE LOADED FAST DISINTEGRANT TABLET: IN- VITRO EVALUATION STUDY

Sachin Shinde*, Gharge Varsha, Bhandwalkar Omkar, Bhandare Pooja, Dadas Tushar, Gadhave Jayant

Abstract

The main objective of the present investigation was to In- Vitro evaluation of ketaconazole tablet formulation of fast disintegrant tablet. Ketoconazole was used the treatment of oral thrushes and systemic infections. The tablets of the ketaconazole were prepared by direct compression technique. Among the different routes of administration, the oral route of administration continues to be the most preferred route. Due to various advantages including ease of ingestion, avoidance of pain, versatility and most importantly patient compliance. Recently fast dissolving tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better In Novel Drug Delivery System (NDDS) aim for designing forms, convenient to be manufactured and administered free side effects, offering immediate release and enhanced bioavailability. The prepared tablets evaluated in terms of their pre-compression studies, post-compression studies and in vitro study. The Disintegration study and In-vitro study showed that formulation of batch F7gives better result than the other batches.

Keywords: Ketoconazole, sodium starch glycolate, enhanced bioavailability, Disintegration study, and In vitro study.