Abstract

A PROSPECTIVE STUDY ON THE EFFECTIVENESS OF METFORMIN AND ETHINYL ESTRADIOL-CYPROTERONE ACETATE IN THE MANAGEMENT OF HYPERANDROGENISM IN POLYCYSTIC OVARY SYNDROME PATIENTS

Mathew George, Lincy Joseph, Bincy K. Chacko and Namitha Susan Reji*

Abstract

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting 5-8% of women of reproductive age group characterized by associated problems such as infertility, diabetes mellitus, hypertension, dyslipidemia, endometrial cancer, depression and hyperandrogenism. The aim of the review is to evaluate the effectiveness of Metformin and Ethinyl Estradiol- Cyproterone Acetate (EE-CA) in the management of Hyperandrogenism in PCOS patients. As there are only few studies in Indian literature regarding the evaluation of effectiveness of the drugs in the management of hyperandrogenism associated with PCOS, the present review is undertaken. The review had shown that EE-CA is a more effective way of treating hyperandrogenism and menstrual dysfunction compared to Metformin which outperforms EE-CA in improving insulin resistance, reducing Body Mass Index and improving ovulation.

Keywords: Hyperandrogenism, Insulin resistance, Metformin, Ethinyl Estradiol- Cyproterone Acetate.