Abstract

SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF SOME NOVEL ISOXAZOLINE DERIVATIVES

Chirag K. Naik and Vikas A. Desai*

Abstract

The isoxazolines are having several interesting applications in the field of medicinal chemistry. We have synthesized a series of 3 - {3’ - (6'' – methoxy - naphthalen-2''-yl) - 5' - (2'' - hydroxy-4''- methoxy phenyl)- 4', 5’-dihydro-1H- pyrazol-1'-yl}-5-(substituted phenyl) - isoxazolines (4a-j). The structures of isoxazoline have been characterized on bases of elemental analysis and spectral data. The compounds were screened for their in vitro antibacterial activity using gram-positive bacteria and gram negative bacteria.

Keywords: Isoxazoline, chalcone, antibacterial activity, heterocyclic synthesis.