Abstract

SYNTHESIS AND BIOLOGICAL SCREENING OF NOVEL CINNOLINE DERIVATIVES FOR ANALGESIC ACTIVITY

*Mathew George, Lincy Joseph and Sony S.

Abstract

An attempt has been made to synthesize a series of Cinnoline derivatives by diazotization reaction of substituted anilines followed by Friedel –Craft acylation to form hydrazones and intramolecular cyclization to form cinnoline derivatives. The synthesized compounds were characterized by analytical techniques like TLC, IR, NMR spectral analysis. All the synthesized derivatives were screened for analgesic activity using acetic acid induced writhing test. Compounds S1 and S5 showed significant activity when compared to standard drug diclofenac sodium (p< 0.01).

Keywords: Cinnoline, analgesic activity, Diclofenac sodium.