Abstract

ATOMIC ABSORPTION SPECTROMETRIC DETERMINATION OF METOCLOPRAMIDE HYDROCHLORIDE USING AMMONIUM REINECKATE

Mohammad Wafaa I. Nassar, Khalid Abdel-Salam M. Attia, Ahmed Abdelhalim A.
Mohamad, Ragab Ahmad M. Said and Rady Fathy A. Gaber*

Abstract

An accurate, rapid and simple atomic absorption spectrometric method was developed for the determination of metoclopramide hydrochloride (MCP-HCl). The proposed method has been depended on the reaction of ammonium reineckate with MCP-HCl to form a stable precipitate of ion-pair complex, which was dissolved in acetone. The pink colored complex was determined by atomic absorption spectrometer at wavelength 357.9 nm. The studied drug could be evaluated in the range of 20 ─ 120 μg/mL. The optimization of various experimental conditions was described. The results obtained showed good accuracy of 99.36 with repeatability of 0.854 and intermediate precision of 1.351. Application of the proposed method to representative pharmaceutical formulation was successfully presented.

Keywords: Ammonium reineckate, atomic absorption spectrometric method, ion-pair complex, metoclopramide.