Abstract

IMPROVEMENT BY THE AQUEOUS EXTRACT OF THE LEAVES OF DESMODIUM VELUTINUM WILL DC (FABACEAE) OF BIOLOGICAL PARAMETERS ALTERED BY ETHANOL 30 % IN RATS

Etou Ossibi A. W.*, Elion Itou R. D. G., Epa C., Mbougou Bouesse B., Gouollaly Tsiba, Okemy Andissa N. and Abena A. A.

Abstract

Most epidemiological data show that regular alcohol consumption isrelated to an increase the occurrence of cardiovascular diseases,dysfunction of noble organs and changes in biochemical andhematological parameters. The objective of this work is to evaluate theeffects of the aqueous extract of the leaves of D. velutinum on theconsequences of the subchronic excessive consumption of ethanol 30% in the wistar rat. Alterations in biological parameters (rat weight,noble organ masses, ALT, ASAT, white blood cells, red blood cells,hemoglobin and platelets) were induced by ethanol overload 30 %daily for eight (8) weeks. The detection of flavonoïds in this extractwas made by Thin Layer Chromatography (TLC). At the doses of 250and 500 mg/kg the aqueous extract improves the biological parameters.This extract contains flavonoïds. Other activities to deepen the effects of the aqueous extractof the leaves of D. velutinum on the alterations of the biological parameters induced by theethanol 30% deserve to be realized.

Keywords: Ethanol 30%, Desmodium velutinum, toxicity, biological parameters, flavonoïds.