Abstract

FLOATING DRUG DELIVERY SYSTEM: AN APPROACH TO GASTRO RETENTION

Rupali S.Wagh*, Poonam A. Salunke, Sheetal V.Patil, Shital S. Patil, Amit Ratnaparkhi, Mayur Pawar, Swati Rathod, Dr. S.D. Barhate

Abstract

The oral route of drug administration is the most convenient and commonly used method of drug delivery. Floating drug delivery systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on the gastric contents the drug is released slowly at a desired rate from the system. After the release of drug, residual system is emptied from the stomach. This result in increase in the gastric residence time and a better control of fluctuation in plasma drug concentration. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug- delivery systems for more than 12 hours. Several approaches are utilized in prolongation of the gastro retention time. In this review, the current technological developments of FDDS and Pharmaceutical basis of their design, advantages and future potential are discussed. In addition marketed products have been discussed.

Keywords: Floating drug delivery systems, its classification and application, Gastric residence time (GRT), Absorption window.