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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL AMIDE DERIVATIVE CONTAINING OXAZOLE MOIETY

Shaikh Sharif* and Dr. Yogen H. Talia

Abstract

In the present study, synthesis of some novel Oxazole contains amide analog [2a-l] have been carried out by condensing N-(4-acetylphenyl)- 2-(10-oxo-10, 11-dihydrodibenzo [b, f] thiepin-2-yl) propanamide with various aromatic derivatives by using ethanol as a solvent in presence of catalyst (Cl2, Br2 or I2) under reflux condition. Structures of synthesized compounds have been confirmed by spectral data (IR, 1H NMR) and elemental analysis. The entire newly synthesized compound has been evaluated for their antibacterial activities.

Keywords: Amide, Oxazole, Reflux, Spectral data, Antimicrobial activity.

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