Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ADIANTUM LUNULATUM BURM.F

*Swathi P. P. and Jyoti Harindran

Abstract

Aim: The present study is to evaluate the Hepatoprotective activity of ethanolic extract of Adiantum lunulatum Burm.f against simvastatin induced hepatotoxicity. Method: The whole plant was extracted using ethanol and hepatotoxicity in rats was induced by the administration of simvastatin (20 mg/kg p.o for 30 days), the protective effect of Adiantum lunulatum Burm. f (200 mg/kg p.o) and (400 mg/kg p.o) for 30 days, and standard silymarin (25mg/kg p.o) for 30 days. Result: The significant changes in Biochemical parameters such as increased Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosphatase (ALP), Serum bilirubin and decrease in Total proteins during simvastatin induced toxicity were restored towards normalization in Adiantum lunulatum Burm.f (200 mg/kg and 400 mg/kg) treated animals. Oxidative stress markers GSH (Reduced glutathione) and SOD (Superoxide dismutase) showed decrease in simvastatin induced group than normal group, and Adiantum lunulatum Burm.f treated groups increases respectively. Histopathological studies also confirmed the protective effect of Adiantum lunulatum Burm.f Conclusion: Thus the present study ascertains that the ethanolic extract of Adiantum lunulatum Burm.f possesses significant hepatoprotective activity and it may due to the antioxidant activity of the plant.

Keywords: Adiantum lunulatum Burm.f, Hepatotoxicity, Antioxidant activity, Simvastatin, Silymarin, Ethanol.