Abstract

DEVELOPMENT OF VALIDATED UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF BAMIFYLLINE IN THE BULK DRUG AND MARKETED FORMULATION

M. Mary Prasanthi*, Farheena S. K., Gowthami A. and K. Sowmya Sravani

Abstract

A simple, sensitive, accurate, precise, and economic UV spectrophotometric method has been developed and validated for the estimation of bamifylline in tablet dosage form. Bamifylline showed maximum absorption at 221, 257 and 273 nm respectively using a UV– Visible spectrophotometer (Jasco, model V-630). Beer’s law was obeyed in the concentration range of 1-10 μg/ml. with a correlation coefficient was found to be 0.999 for drug. The method was validated for various parameters according to ICH guidelines. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. Assay results were in good agreement with label claim.

Keywords: Bamifylline, UV spectrophotometric method.