Abstract

OCULAR DRUG DELIVERY SYSTEM: A REVIEW

Bhujbal S.S.*, Wale K.K., Mahale N.B.,Landage A.D.,Sayyed S.F.,Chaudhari S.R

Abstract

Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical companies in the market. In ophthalmic formulation to the eye like solutions, suspensions, and ointments are available in the market shows drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision. The major problem associated with the convent ional dosage forms is the bioavailability of drug. In the last three decades to improve the bioavailability by common to adding viscosity-enhancing agents or mucoadhesive polymers into dosage formulations. To overcome to conventional dosage formulations there were non-conventional technologies such as nanotechnology, microspheres, micro emulsion and ocular inserts could be developed in pharmaceutical market. This review focuses on recent development in conventional and nonconventional ophthalmic dosage formulation and products used to achieve prolonged contact time of drugs with the cornea and increases their bioavailability.

Keywords: Eye, ophthalmic formulations, polymers, sustained release, nanotechnology