Abstract

BIOLOGICAL EVALUATION OF GARLIC LEAVES EXTRACTS FOR CARBOHYDRATE METABOLISM, IN VITRO

Gangadhar A. Meshram*, Tanushri S. Kulkarni, Ganesh S. Metangale, Shraddha S. Khamkar

Abstract

Allium Sativum. Linn (Garlic) is one of the widely used herbs in food and medicine. The cloves of garlic are investigated for anti-diabetic potential; however, no efforts have been made to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α- amylase and glucoamylase. The inhibitors of these enzymes are used to achieve greater control over hyperglycemia in Type II Diabetes Mellitus. The present work was designed to investigate the inhibitory potential of the different extracts of Allium Sativum, on enzymes α- amylase and glucoamylase. Different concentrations of the extracts were used to study inhibition of enzymatic activity of those enzymes. The current study for the first time, revealed α-amylase and glucoamylase inhibitory potential of A. Sativum leaves and the study could be helpful to isolate and characterize hypoglycemic compounds.

Keywords: ?-amylase, glucoamylase, Allium Sativum leaves, hypoglycemic