Abstract

THE SYNERGISTIC EFFECT OF ETHANOL LEAF EXTRACT OF ANNONA MURICATA AND ARTOCARPUS HETEROPHYLLUS ON HIGH FAT DIET INDUCED HYPERLIPIDAEMIA IN WISTAR ALBINO RATS

C. L. Onuah*, F. C. Anacletus, A. A. Uwakwe and P. N. Okoroh

Abstract

The antihyperlipidaemic and antihypertensive effects of ethanol leaf extract of Annona muricata, Artocarpus heterophyllus and combined ethanol leaf extract of Annona muricata and Artocarpus heterophyllus on male wistar albino rats were studied. Forty eight (48) rats were given high fat diet (HFD) to induce hyperlipidaemia. The rats were treated with 200mg/kg body weight of A. muricata and A. heterophyllus, 100 and 200mg/kg body weight of combined ethanol leaf extract of A. muricata and A. heterophyllus. Ethanol leaf extract of A. muricata and A. heterophyllus had a positive effect on the total cholesterol, triglyceride, and high density lipoprotein level of the diabetic rats. The effects of the combined ethanol leaf extract on the heart tissue oxidative stress markers of the rats were also studied. A decrease which is statistically significant at p

Keywords: Hyperlipedeamia, oxidative stress, antihyperlipidaemia, blood pressure, High fat diet, wistar albino rats.