Abstract

A REVIEW ON ESTIMATION OF DAPAGLIFLOZIN AND METFORMIN HCL IN BULK AND IN PHARMACEUTICAL DOSAGE FORM

Priyanka R. Varade*, Dr. N. S. Dighe, Prof. G. S. Shinde and Sachin K. Nawathe

Abstract

Diabetes mellitus is a chronic, progressive, incompletely understood metabolic condition chiefly characterize by hyperglycemia. Dapagliflozin is a sodium-glucose co transporter 2 inhibitors (SGLT2) as a new class of oral antidiabetic drugs. It is indicated for treatment of Diabetes mellitus type 2, either alone or in combination with Metformin hydrochloride. The aim of this review is to focus on update of determination of Dapagliflozin and Metformin hydrochloride in bulk and in pharmaceutical preparation using RP-HPLC and UV spectrophotometric method. This review provides detailed information on separation for Dapagliflozin alone and in combination with Metformin hydrochloride.

Keywords: Dapagliflozin, Metformin hydrochloride, RP-HPLC, UV- Spectroscopy.