Abstract

EVALUATION OF IN VIVO ANTIUROLITHIATIC ACTIVITY OF WHOLE PLANT OF SPERMACOCE HISPIDA (LINN) K. SCHUM

Prasanth S.* and Veena R.

Abstract

Urolithiasis is a common urological disorder responsible for serious human affliction and cost to the society with a high rate of reoccurrence and treatment failure. Aim: The aim of the present study was to systematically evaluate the antiurolithiatic activity of ethanolic extract of whole plant of Spermacoce hispida (Linn). Materials and Methods: Calcium oxalate urolithiasis was induced in male wistar albino rats using calculi producing diet (5% sodium oxalate and rat pellet feed). The biochemical parameters like calcium, oxalate, creatinine, creatinine clearance, blood urea nitrogen, magnesium, potassium, and sodium were evaluated in urine, serum. At the end of experiment 24hr urine samples were collected for urinary estimation (urinary calcium, oxalate, creatinine) and blood was collected from retro orbital sinus and used for the estimation of BUN, creatinine, and creatinine clearance. Results: The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by treatment with ethanolic extract of Spermacoce hispida L. Conclusion: From this study, we conclude that the treatment with ethanolic extracts of Spermacoce hispida L. had an inhibitory effect on crystal growth, with improvement of kidney function.

Keywords: Urolithiasis, Spermacoce hispida (Linn), CPD (calculi produced diet), sodium oxalate, antiurolithiatic activity.