Abstract

MODULATING EFFECTS OF GINKO BILOBA IN CYCLOPHAMIDE INDUCED GENETIC DAMAGE IN SWISS ALBINO MICE

Ravi Prasad, *K. Rudrama Devi and K. Pratap Reddy

Abstract

The present study the experiments were carried out to investigate the possible protective effect of Ginkgo biloba extract (GBE) on germ cells damage induced by the anticancer drug cyclophosphamide (CP) in male albino mice. The animals treated with various doses of Ginkgo biloba 200, 400 & 600 mg/kg individually and primed after cyclophosphmaide treatment. The animals were sacrificed on 35th day by cervical dislocation and slides were prepared according to the standard method. The prepared slides were screened for the presence of different type of sperms head abnormalities in control and treated mice. The results showed when animals treated with CP caused significant increase in the percentage of aberrant sperms in germ cells of mice. However after co administration of three doses of GBE extract there was a dose dependent decrease in % of aberrant sperms. Thus the results clearly indicate the protective role of GBE on Cyclophosphamide induced genotoxic damage in germ cells of mice. The results of this study indicated that GBE protected mice against CP induced germ cell damage. Such studies are useful chemo therapeutic strategy.

Keywords: Cyclophosphamide, Ginkgo biloba, Aberrant Sperms Protection.