Abstract

FORMULATION AND EVALUATION OF PHYTOSOMAL NANOCARRIERS FOR ENHANCED CHRYSIN DELIVERY

Annamma Anthrayose* and Neema George

Abstract

The present work was designed to improve solubility and bioavailability of Chrysin by the development of Chrysin loaded nanophytosomes by rotary evaporation method. The formulation of phytosome evaluated for particle size ,zeta potential, SEM, FTIR, DSC, entrapment efficiency, drug content, solubilty , in vitro drug release and release kinetics. The particle size by DLS was found to be in nano size range. The SEM, FTIR, DSC and solubility analysis confirmed the formation of phytosome. Chrysin nanophytosome showed better in vitro drug release when compared to Chrysin. The kinetics of the drug release was found that it predominately follows zero order and Higuchi kinetics with non fickian diffusion mechanism.

Keywords: Chrysin, flavanoid, nanocarrier, nanophytosome, rotary evaporation.