Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NAPROXEN USING DIFFERENT CARRIERS BY SOLID DISPERSION TECHNIQUE

Katta Manogna*, P. Nagaveni and K. Thyagaraju

Abstract

In the present study an attempt has been made to increase the in vitro dissolution rate of poorly water-soluble drug naproxen, by employing novel solid dispersion methods are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drug. Naproxen formulations were prepared by using melting-solvent method, and using carrier like urea and PEG4000. The formulation were prepared with the above mentioned carriers in three different drug-carrier (w/w) ratios of 1:1, 1:2 and 1:3. The prepared solid dispersion was subjected for percentage practical yield, drug content, and FT-IR and DSC studies. Absence of significant drug-carrier interaction was confirmed by FTIR and DSC data. In-vitro release profiles of all solid dispersions (F-1 to F-6) were comparatively evaluated and also studied against pure naproxen. The drug release from all the solid dispersion displayed nearly zero-order release kinetics with (r) values ranging from approximately 0.993. Solid dispersion of formulation (F3) naproxen and urea combination prepared in (1:3) ratio showed excellent solubility and the dissolution rate was found to be 98.32% drug release at 30 min was selected as the best formulation in this study. Solubility of naproxen was increased as the concentration of carriers increased.

Keywords: Naproxen, Urea, PEG4000, Enhancement dissolution, Solid dispersion, Melting- solvent method, Dissolution rate, structure, Pharmacokinetic, metastable form.